Portfolio manager comments — Q2 2025
Fund performance was weak during the second quarter and declined by 10% in SEK.
The main reason was continued uncertainty related to the Trump administration’s trade policy, particularly regarding tariffs and proposals to align US drug prices with international levels.
The largest negative contributor was UnitedHealth, which continues to face profitability pressure and risks related to potential changes in the US healthcare system that could negatively impact its business model. The company has long been one of the fund’s largest holdings and a significant positive contributor, but now we have substantially reduced the position.
On the positive side was the Belgian pharmaceutical company UCB, which continues to gain market share with its psoriasis drug Bimzelx. The company also has regulatory applications under review for additional dermatological indications.
The fund also benefited from holdings in diagnostics companies Natera (US) and Devyser (Sweden), both of which contributed positively during the period.
On the negative side was Japan’s Daiichi Sankyo, which declined after clinical trial results failed to meet market expectations. However, we believe the company’s research pipeline still has the potential to deliver positive surprises.
In the obesity segment, Zealand Pharma continued to underperform, which may seem contradictory given its recently announced partnership with Roche—a collaboration that could generate significant revenue in the coming years.
Argenx also contributed negatively after some patients failed to respond as expected in CIDP treatment studies.
New holdings include Nurix Therapeutics, a biotech company focused on degrader technology, and China’s CSPC Pharma, which collaborates with companies including AstraZeneca in AI and drug development.
Valuations in the healthcare sector have come down significantly this year, making the area more attractive. However, greater clarity is needed regarding tariffs and the Trump administration’s MFN proposal before the market can fully price in the underlying demand.