Portfolio manager comments — Q1 2025
Fund performance was negative during the quarter. In January, market sentiment was positive ahead of Trump taking office as president. However, the remainder of the quarter was characterized by more negative market outlooks due to the political uncertainty, particularly in the US.
A lack of transparency about the policies of the new US administration and uncertainty regarding how it intends to handle several aspects within US healthcare remained during the quarter. Among others, the health insurance system, vaccination program, as well as the mandate of the regulatory authority (FDA) and government financing of medical research (NIH) appears to initially be affected by the Trump administration’s politics. Concerns about the impact of possible tariffs on the sector also affected several healthcare equities and the fund.
Among the fund’s strongest contributors was Halozyme, which raised its outlooks for earnings, royalties, and growth for 2025. Growth is being driven primarily by the VYVGART Hytrulo drug (in partnership with the company argenx), which is used for the treatment of autoimmune diseases.
On the negative side was Novo Nordisk, whose stock continues to be put under pressure by concerns about further competition from so-called compounders in the US, as well as by the upcoming study data for an obesity drug in tablet form by its competitor, Eli Lilly. Bicyle Therapeutic also had a negative impact due to a weaker than expected report for Q4 2024.